Knowledge empowers better conversations, better decisions, and greater hope.

The science of Graves’ Disease and Thyroid Eye Disease is advancing more rapidly than ever before. Researchers around the world are expanding our understanding of these autoimmune conditions while developing new treatments that offer renewed hope for patients and families. Here you’ll find clinical trials, research publications, educational articles, and trusted resources to help you stay informed as new discoveries continue to shape the future of care.

argenx clinical trial for graves disease

Clinical Trials

The future of Graves’ Disease and Thyroid Eye Disease treatment is being written today through clinical research. Around the world, physicians, scientists, and patients are working together to better understand these autoimmune conditions and to develop therapies that target the underlying disease—not just its symptoms. Recent scientific advances have already transformed the treatment landscape for Thyroid Eye Disease, and a new generation of investigational therapies for Graves’ Disease is now being actively studied.

Clinical trials are carefully designed research studies that evaluate the safety and effectiveness of new medications and treatment approaches. Participation is always voluntary, and every study has specific eligibility criteria to help ensure participant safety. While not every clinical trial is appropriate for every individual, each study contributes valuable knowledge that helps move medicine forward and creates hope for future generations. We encourage you to explore the opportunities below and discuss any potential participation with your healthcare team.

graves disease and thyroid eye disease clinical trials

Clinical Trials 101

What Is a Clinical Trial?

A clinical trial is a carefully designed research study that evaluates new medications, therapies, medical devices, or treatment approaches. Clinical trials help researchers determine whether a new treatment is safe, effective, and may improve the lives of people living with Graves’ Disease and Thyroid Eye Disease (TED).

How Clinical Trials Work

1. Research Begins

Scientists identify a promising treatment based on years of laboratory research and begin studying how it works.

2. Preclinical Testing

Before a treatment is tested in people, it is evaluated in laboratory and animal studies to better understand its safety and potential effectiveness.

3. Clinical Trial Phases

If the treatment shows promise, it moves into clinical trials involving volunteers. These studies are conducted in phases, each designed to answer specific questions about safety, dosage, effectiveness, and side effects.

4. Safety Is the Highest Priority

Every clinical trial follows strict ethical and scientific standards. Participants are carefully monitored throughout the study, and independent review boards oversee participant safety.

5. Results Are Evaluated

Researchers analyze the data to determine whether the treatment is safe, effective, and offers meaningful benefits compared to current standards of care.

6. Regulatory Review

If the results are positive, the study findings are submitted to regulatory agencies, such as the U.S. Food and Drug Administration (FDA), for review before a treatment can become available to the public.

7. New Treatments Become Available

When approved, new therapies become additional treatment options for patients and healthcare providers, helping improve care for future generations.

Why Clinical Trials Matter

Clinical trials are the foundation of medical progress. Every treatment available today was once carefully studied in a clinical trial. Participation helps researchers better understand diseases, improve existing therapies, and develop innovative treatments that may benefit countless people in the future.

Participation Is Always Voluntary

Choosing to participate in a clinical trial is a personal decision. Every study has specific eligibility requirements, and participants receive detailed information before deciding whether to enroll. You are free to leave a clinical trial at any time.

If you are interested in participating, discuss the opportunity with your healthcare provider to determine whether a particular study may be appropriate for you.

You Can Make a Difference

Behind every medical breakthrough are individuals who chose to participate in research. Their willingness to contribute has helped advance science, improve treatment options, and create hope for future generations living with Graves’ Disease and Thyroid Eye Disease.

Graves’ Disease Clinical Trial ~ Recruiting Soon

Argenx partner for ted community organization supporting graves' disease education

Official Study Name:
A Study to Assess Efficacy and Safety of Efgartigimod PH20 SC PFS in Adult Participants With Graves’ Disease (VitaliThy)

https://clinicaltrials.gov/study/NCT07596849

https://clinicaltrials.gov/study/NCT07570316

ClinicalTrials.gov ID: NCT07596849
• Other study numbers: ARGX-113-25-GRD-3001; ARGX-113-25-GRD-3002
• 2025-524223-42-00 ( EU Trial (CTIS) Number )
• 2025-523333-26-00 ( EU Trial (CTIS) Number )

Mode of delivery: Subcutaneous injection via Prefilled Syringe (PFS)

Primary Outcome Measure:
Percentage of participants who are euthyroid (fT3, fT4, and TSH within normal ranges) off ATDs at week 24 in part A

TED Clinical Trial ~ Actively Recruiting

kriya partner for ted community organization supporting graves' disease education

Kriya Therapeutics is a biopharmaceutical company developing gene therapies to address common chronic diseases of high unmet need. Our mission is to make gene therapies accessible – not just for the few – but for the many.

Kriya is developing KRIYA-586, an investigational one-time gene therapy for thyroid eye disease (TED) designed to be delivered by an in-office peribulbar injection. KRIYA-586 is an adeno-associated virus (AAV) gene therapy engineered to express an antibody that inhibits Insulin-Like Growth Factor 1 Receptor (IGF1R).

The RECLAIM Study is an adaptive Phase 1/2 multicenter study evaluating the safety, tolerability, pharmacokinetics, and efficacy of KRIYA-586 in patients with moderate to severe TED.

Thyroid Eye Disease Clinical Trial
https://clinicaltrials.gov/study/NCT07404111

KRIYA-586 is an investigational therapy and has not been approved as safe or effective by the FDA or any other regulatory health authority.

Resources for Graves’ Disease & TED

Patient Organizations

TED Community Organization
https://tedcommunity.org

British Thyroid Foundation
https://www.btf-thyroid.org

Thyroid Eye Disease Charitable Trust
https://www.tedct.org.uk

Thyroid Federation International
https://thyroid-fed.org

*

Medical Organizations

American Thyroid Association
https://www.thyroid.org

American Association of Clinical Endocrinology (AACE)
https://www.aace.com

National Eye Institute (NIH)
https://www.nei.nih.gov

Prevent Blindness
https://preventblindness.org

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Research & Clinical Trials

PubMed
https://pubmed.ncbi.nlm.nih.gov

National Library of Medicine
https://www.nlm.nih.gov

ClinicalTrials.gov
https://clinicaltrials.gov

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Financial Assistance

The Assistance Fund
https://tafcares.org

How to Know if a Health Website Can Be Trusted

How to Know if a Health Website Can Be Trusted

The internet provides instant access to an incredible amount of health information—but not all of it is accurate, current, or trustworthy. Learning how to evaluate medical information can help you make informed decisions and have better conversations with your healthcare team.

1. Written or Reviewed by Qualified Medical Professionals

Look for content that is written or reviewed by physicians, nurses, pharmacists, researchers, or other licensed healthcare professionals with expertise in the topic. Reputable websites identify their authors and explain their qualifications.

2. References Scientific Research

Trustworthy health information is supported by scientific evidence. Look for references to peer-reviewed research studies, medical journals, respected academic institutions, or established professional organizations rather than opinions or anecdotal claims alone.

3. Updated Regularly

Medical knowledge continues to evolve. Check when an article was published or last reviewed to help ensure the information reflects current research, treatment recommendations, and clinical guidelines.

4. Clearly Identifies Its Sources

Reliable websites are transparent about where their information comes from. They provide citations, references, or links to original research, professional organizations, or government health agencies so readers can verify the information themselves.

5. Does Not Promise Miracle Cures

Be cautious of websites that promise quick fixes, guaranteed cures, or “secret” treatments. If something sounds too good to be true, it probably is. Trustworthy organizations discuss both the benefits and limitations of treatments while acknowledging that every person’s experience is unique.

Using AI for Health Research

Artificial intelligence is becoming an increasingly valuable tool for learning about health conditions, summarizing research, and helping people ask better questions. Like any tool, however, it should be used thoughtfully.

AI Can Help You

  • Learn about Graves’ Disease and Thyroid Eye Disease.
  • Understand medical terminology.
  • Summarize complex research articles.
  • Prepare questions for your healthcare appointments.
  • Compare treatment options based on published information.
  • Find reputable educational resources more efficiently.

Use AI Wisely

Always verify important medical information using trusted sources such as medical organizations, scientific research, government health agencies, or your healthcare provider. AI systems can occasionally make mistakes, misunderstand medical literature, or provide outdated information.

Never rely on AI alone to diagnose a condition, recommend treatment, or make important medical decisions. Instead, think of AI as a knowledgeable research assistant that helps you become a more informed and engaged partner in your healthcare.

Our Commitment

TED Community carefully selects resources that are:

  • Evidence-based
  • Patient-centered
  • Reviewed against trusted medical sources
  • Designed to help you make informed decisions—not replace professional medical advice

Our goal is to empower every member of the Graves’ Disease and Thyroid Eye Disease community with information that is accurate, understandable, compassionate, and grounded in the best available science.

The most powerful healthcare decisions happen when informed patients, experienced healthcare professionals, and trusted technology work together.

Featured Articles on Graves’ Disease & Thyroid Eye Disease

Graves’ Disease: Is It Time for Targeted Therapy?

Publication: Medicina (2025)

A fascinating review of the next generation of Graves’ Disease treatments, including therapies designed to interrupt the autoimmune process itself rather than simply treating symptoms.

Recent Advances in the Management of Graves’ Disease

Publication: Current Opinion in Endocrinology, Diabetes and Obesity

A review of evolving treatment options, including long-term antithyroid medications and emerging targeted therapies.

The Evolving Therapeutic Landscape of Graves’ Disease

Publication: European Thyroid Journal (2025)

An excellent overview of where Graves’ Disease treatment is headed over the next decade.

Management Aspects of Medical Therapy in Graves Disease

Publication: Endocrine Practice (2025)

A practical review discussing current medical treatments and how physicians make treatment decisions.

Targeted Immunotherapies for Graves’ Thyroidal & Orbital Disease

Publication: Frontiers in Immunology (2025)

Explores exciting new immune-based therapies currently being studied for Graves’ Disease and TED.

The Burden of Illness in Thyroid Eye Disease

Publication: Ophthalmology and Therapy (2025)

Examines how TED affects vision, quality of life, mental health, and daily living.

25-Year Outcomes After Graves’ Disease Treatment

Publication: Journal of Clinical Endocrinology & Metabolism (2024)

One of the most important long-term studies examining remission, relapse, and quality of life decades after treatment.

Thyroid Eye Disease: What’s the Latest?

Publication: Cleveland Clinic Journal of Medicine (2025)

An excellent physician-written update explaining the newest understanding of TED and current treatment options.

Mayo Clinic Guide to Graves’ Disease

Publication: Mayo Clinic

A trusted patient-friendly overview covering symptoms, diagnosis, and treatment options.

Graves Disease

Publication: StatPearls / National Library of Medicine

A comprehensive overview that bridges patient education and professional medical information.

Patient Preferences and Expectations in Graves’ Disease

Publication: Patient Preference and Adherence (2025)

An insightful review highlighting how Graves’ Disease affects emotional wellbeing, decision-making, and quality of life.

Thyroid: Year in Review 2024–2025

Publication: Endocrine Practice

A summary of the year’s most important thyroid research, including Graves’ Disease, TED, selenium studies, gut microbiome research, and emerging therapies.